Title : Induction of heme oxygenase 1 by nitrosative stress. A role for nitroxyl anion.

Pub. Date : 2002 Oct 25

PMID : 12194971






2 Functional Relationships(s)
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1 N-Acetylcysteine almost completely abolished AS-mediated induction of HO-1, whereas a glutathione synthesis inhibitor (buthionine sulfoximine) significantly decreased heme oxygenase activation by AS, indicating that sulfydryl groups are crucial targets in the regulation of HO-1 expression by NO(-). sulfydryl heme oxygenase 1 Rattus norvegicus
2 N-Acetylcysteine almost completely abolished AS-mediated induction of HO-1, whereas a glutathione synthesis inhibitor (buthionine sulfoximine) significantly decreased heme oxygenase activation by AS, indicating that sulfydryl groups are crucial targets in the regulation of HO-1 expression by NO(-). sulfydryl heme oxygenase 1 Rattus norvegicus