Pub. Date : 2002 Sep
PMID : 12181452
3 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | This report examines the regulation of CYP2C9 with respect to two specific receptors thought to be involved in phenobarbital (PB) induction, the constitutive androstane receptor (CAR) and pregnane X receptor (PXR). | Phenobarbital | cytochrome P450 family 2 subfamily C member 9 | Homo sapiens |
| 2 | This report examines the regulation of CYP2C9 with respect to two specific receptors thought to be involved in phenobarbital (PB) induction, the constitutive androstane receptor (CAR) and pregnane X receptor (PXR). | Phenobarbital | cytochrome P450 family 2 subfamily C member 9 | Homo sapiens |
| 3 | In summary, a new CAR/PXR binding site was identified in the CYP2C9 promoter, and this site seems to constitutively regulate transcription via a CAR-dependent mechanism; however, it could not be shown to account for PB inducibility of the gene. | Phenobarbital | cytochrome P450 family 2 subfamily C member 9 | Homo sapiens |