Pub. Date : 2002 Aug
PMID : 12171903
5 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | We reported recently that human carboxylesterase-2 (hCE-2) is a higher-affinity, higher-velocity enzyme for irinotecan hydrolysis when compared with hCE-1. | Irinotecan | carboxylesterase 2 | Homo sapiens |
| 2 | We reported recently that human carboxylesterase-2 (hCE-2) is a higher-affinity, higher-velocity enzyme for irinotecan hydrolysis when compared with hCE-1. | Irinotecan | carboxylesterase 2 | Homo sapiens |
| 3 | Extracts of HT29 cells transfected with hCE-2 exhibited significantly higher irinotecan hydrolysis (5.2 pmol/mg protein/hr) than hCE-1 (1.0 pmol/mg protein/hr). | Irinotecan | carboxylesterase 2 | Homo sapiens |
| 4 | HT29 cells over-expressing hCE-2 were more sensitive to the toxic effects of irinotecan than cells expressing hCE-1 (EC50 = 0.3 micro M and 6.8 micro M, respectively). | Irinotecan | carboxylesterase 2 | Homo sapiens |
| 5 | Our data further support the notion that hCE-2 plays a substantial role in irinotecan activation in human tissue at relevant pharmacologic concentrations. | Irinotecan | carboxylesterase 2 | Homo sapiens |