CPRiL

4 Functional Relationships(s) Download
	Sentence	Compound Name	Protein Name	Organism
1	Northern blot analysis was used to quantify the expression of COX-2 in first-passage cultures of equine articular chondrocytes propagated in media containing dexamethasone (DEX), phenylbutazone (PBZ), polysulfated glycosaminoglycan, and hyaluronan, each at concentrations of 10 and 100 microg/ml and each with or without reIL-1beta.	Dexamethasone	cytochrome c oxidase subunit II	Equus caballus
2	Northern blot analysis was used to quantify the expression of COX-2 in first-passage cultures of equine articular chondrocytes propagated in media containing dexamethasone (DEX), phenylbutazone (PBZ), polysulfated glycosaminoglycan, and hyaluronan, each at concentrations of 10 and 100 microg/ml and each with or without reIL-1beta.	Dexamethasone	cytochrome c oxidase subunit II	Equus caballus
3	Concentration of PGE2 in spent medium from reIL-beta-treated chondrocytes was significantly reduced by DEX and PBZ; however, only DEX significantly reduced gene expression of COX-2.	Dexamethasone	cytochrome c oxidase subunit II	Equus caballus
4	Palliative relief in affected horses is probably attributable, in part, to inhibition of PGE2 synthesis; however, analysis of these data suggests that of the 4 compounds tested, only DEX affects pretranslational regulation of the COX-2 gene in cultured equine chondrocytes.	Dexamethasone	cytochrome c oxidase subunit II	Equus caballus