PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 12171167-4 2002 Northern blot analysis was used to quantify the expression of COX-2 in first-passage cultures of equine articular chondrocytes propagated in media containing dexamethasone (DEX), phenylbutazone (PBZ), polysulfated glycosaminoglycan, and hyaluronan, each at concentrations of 10 and 100 microg/ml and each with or without reIL-1beta. Dexamethasone 158-171 cytochrome c oxidase subunit II Equus caballus 62-67 12171167-4 2002 Northern blot analysis was used to quantify the expression of COX-2 in first-passage cultures of equine articular chondrocytes propagated in media containing dexamethasone (DEX), phenylbutazone (PBZ), polysulfated glycosaminoglycan, and hyaluronan, each at concentrations of 10 and 100 microg/ml and each with or without reIL-1beta. Dexamethasone 173-176 cytochrome c oxidase subunit II Equus caballus 62-67 12171167-7 2002 Concentration of PGE2 in spent medium from reIL-beta-treated chondrocytes was significantly reduced by DEX and PBZ; however, only DEX significantly reduced gene expression of COX-2. Dexamethasone 130-133 cytochrome c oxidase subunit II Equus caballus 175-180 12171167-9 2002 Palliative relief in affected horses is probably attributable, in part, to inhibition of PGE2 synthesis; however, analysis of these data suggests that of the 4 compounds tested, only DEX affects pretranslational regulation of the COX-2 gene in cultured equine chondrocytes. Dexamethasone 183-186 cytochrome c oxidase subunit II Equus caballus 230-235