Title : Crystal structures of native and thrombin-complexed heparin cofactor II reveal a multistep allosteric mechanism.

Pub. Date : 2002 Aug 20

PMID : 12169660






1 Functional Relationships(s)
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Compound Name
Protein Name
Organism
1 HCII inhibits thrombin, the final protease of the coagulation cascade, in a glycosaminoglycan-dependent manner that involves the release of a sequestered hirudin-like N-terminal tail for interaction with thrombin. Glycosaminoglycans serpin family D member 1 Homo sapiens