Title : Inactivation of NF-kappaB-dependent cell survival, a novel mechanism for the proapoptotic function of c-Abl.

Pub. Date : 2002 Sep

PMID : 12167702






1 Functional Relationships(s)
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1 In contrast to the serine 32/34 phosphorylation that triggers ubiquitination and degradation of IkappaBalpha, c-Abl-mediated phosphorylation at tyrosine 305 is associated with an increase of the IkappaBalpha protein stability. Serine ABL proto-oncogene 1, non-receptor tyrosine kinase Homo sapiens