Title : Beta2 adrenergic receptor activation. Modulation of the proline kink in transmembrane 6 by a rotamer toggle switch.

Pub. Date : 2002 Oct 25

PMID : 12167654






1 Functional Relationships(s)
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1 In the beta(2) adrenergic receptor, mutation of Cys(6.47) to Thr, which in an alpha-helix has a different rotamer distribution from Cys and Ser, produced a constitutively active receptor, whereas the Ser mutant was similar to wild-type receptor. Threonine adrenoceptor beta 2 Homo sapiens