Title : The interactions of a selective protein kinase C beta inhibitor with the human cytochromes P450.

Pub. Date : 2002 Sep

PMID : 12167559






2 Functional Relationships(s)
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Compound Name
Protein Name
Organism
1 Of the nine cDNA-expressed P450s examined, only CYP3A4 and CYP2D6 formed N-desmethyl LY333531. ruboxistaurin cytochrome P450 family 3 subfamily A member 4 Homo sapiens
2 LY333531 and N-desmethyl LY333531 were also examined for their ability to inhibit metabolism mediated by CYP2D6, CYP2C9, CYP3A, and CYP1A2. ruboxistaurin cytochrome P450 family 3 subfamily A member 4 Homo sapiens