Title : Anticholinesterase activity of compounds related to geneserine tautomers. N-Oxides and 1,2-oxazines.

Pub. Date : 2002 Aug 15

PMID : 12166941






2 Functional Relationships(s)
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1 Evaluation of their biological action to inhibit human acetylcholinesterase (AChE) and butyrylcholinesterase (BChE), ex vivo, demonstrated that the N-oxide (7, 9, 11, 13, 15) and 1,2-oxazine (6, 8, 10, 12, 14) structures possessed similar potencies against AChE, but the latter structures were more potent against BChE. n-oxide butyrylcholinesterase Homo sapiens
2 Evaluation of their biological action to inhibit human acetylcholinesterase (AChE) and butyrylcholinesterase (BChE), ex vivo, demonstrated that the N-oxide (7, 9, 11, 13, 15) and 1,2-oxazine (6, 8, 10, 12, 14) structures possessed similar potencies against AChE, but the latter structures were more potent against BChE. n-oxide butyrylcholinesterase Homo sapiens