Title : Enantioselective disposition of lansoprazole in extensive and poor metabolizers of CYP2C19.

Pub. Date : 2002 Jul

PMID : 12152007






1 Functional Relationships(s)
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1 RESULTS: The plasma concentrations of R(+)-lansoprazole were consistently higher than those of the S(-)-enantiomer in both extensive and poor metabolizers of CYP2C19, and the mean area under the plasma concentration-time curve of the (+)- and (-)-enantiomers showed 4.3- and 5.8-fold differences between poor and extensive metabolizers, respectively. Dexlansoprazole cytochrome P450 family 2 subfamily C member 19 Homo sapiens