Pub. Date : 2002 Jul 12
PMID : 12150965
6 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | Isoflavones regulate interleukin-6 and osteoprotegerin synthesis during osteoblast cell differentiation via an estrogen-receptor-dependent pathway. | Isoflavones | interleukin 6 | Homo sapiens |
| 2 | The hypothesis tested in this in vitro study was that the expression and production of dietary isoflavone-mediated osteoclastogenesis-regulatory cytokines, such as interleukin-6 (IL-6) and osteoprotegerin (OPG), are related to the different levels of estrogen receptors expressed in two hFOB osteoblastic cell lines. | Isoflavones | interleukin 6 | Homo sapiens |
| 3 | The hypothesis tested in this in vitro study was that the expression and production of dietary isoflavone-mediated osteoclastogenesis-regulatory cytokines, such as interleukin-6 (IL-6) and osteoprotegerin (OPG), are related to the different levels of estrogen receptors expressed in two hFOB osteoblastic cell lines. | Isoflavones | interleukin 6 | Homo sapiens |
| 4 | The increased expression of OPG and decreased IL-6 production by isoflavones were dose-dependent. | Isoflavones | interleukin 6 | Homo sapiens |
| 5 | After adding the ER binding blocker, ICI-182,780, the effects of isoflavones on OPG and IL-6 production disappeared. | Isoflavones | interleukin 6 | Homo sapiens |
| 6 | In summary, the inhibition by dietary isoflavones of IL-6 production and the stimulation of OPG appear to be mediated, at least in part, via a genomic pathway operating through estrogen receptors and gene expression mechanisms. | Isoflavones | interleukin 6 | Homo sapiens |