Title : Clinical resistance to the kinase inhibitor STI-571 in chronic myeloid leukemia by mutation of Tyr-253 in the Abl kinase domain P-loop.

Pub. Date : 2002 Aug 6

PMID : 12149456






1 Functional Relationships(s)
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1 Mutations of Thr-315 in the Abl kinase domain to Ile (T315I) were previously described in STI-571-resistant patients and likely cause resistance from steric interference with drug binding. Threonine ABL proto-oncogene 1, non-receptor tyrosine kinase Homo sapiens