Title : Cytoplasmic compartmentation of Gln3 during nitrogen catabolite repression and the mechanism of its nuclear localization during carbon starvation in Saccharomyces cerevisiae.

Pub. Date : 2002 Oct 4

PMID : 12140287






2 Functional Relationships(s)
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1 Regulated intracellular localization of Gln3, the transcriptional activator responsible for nitrogen catabolite repression (NCR)-sensitive transcription, permits Saccharomyces cerevisiae to utilize good nitrogen sources (e.g. glutamine and ammonia) in preference to poor ones (e.g. proline). Glutamine nitrogen-responsive transcriptional regulator GLN3 Saccharomyces cerevisiae S288C
2 Here we show that nuclear localization of Gln3 during carbon starvation derives from its indirect effects on nitrogen metabolism, i.e. Gln3 does not move into the nucleus of carbon-starved cells if glutamine rather than ammonia is provided as the nitrogen source. Glutamine nitrogen-responsive transcriptional regulator GLN3 Saccharomyces cerevisiae S288C