Title : Fibrillar inclusions and motor neuron degeneration in transgenic mice expressing superoxide dismutase 1 with a disrupted copper-binding site.

Pub. Date : 2002 Jul

PMID : 12127151






1 Functional Relationships(s)
Download
Sentence
Compound Name
Protein Name
Organism
1 To test the hypothesis that the toxicity of mutant SOD1 originates in Cu(2+)-mediated formation of toxic radicals, we generated transgenic mice that express human SOD1 that encodes disease-linked mutations at two of the four histidine residues that are crucial for the coordinated binding of copper (H46R/H48Q). Histidine superoxide dismutase 1 Homo sapiens