Pub. Date : 2002 Jul
PMID : 12127151
1 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
1 | To test the hypothesis that the toxicity of mutant SOD1 originates in Cu(2+)-mediated formation of toxic radicals, we generated transgenic mice that express human SOD1 that encodes disease-linked mutations at two of the four histidine residues that are crucial for the coordinated binding of copper (H46R/H48Q). | Histidine | superoxide dismutase 1 | Homo sapiens |