Title : [Effects of macrophage colony-stimulating factor on production of estradiol and progesterone by human luteinized granulosa cells in vitro and detection of macrophage colony-stimulating factor receptor on human luteinized granulosa cells].

Pub. Date : 2002 Jun 18

PMID : 12126567






4 Functional Relationships(s)
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1 OBJECTIVE: To investigate the effects of macrophage colony-stimulating factor (M-CSF) on estradiol and progesterone production by human luteinized granulosa cells in vitro and to detect M-CSF receptor in human granulosa cells. Estradiol colony stimulating factor 1 Homo sapiens
2 OBJECTIVE: To investigate the effects of macrophage colony-stimulating factor (M-CSF) on estradiol and progesterone production by human luteinized granulosa cells in vitro and to detect M-CSF receptor in human granulosa cells. Estradiol colony stimulating factor 1 Homo sapiens
3 Thus M-CSF caused a significant dose dependent increase of estradiol and progesterone production (P < 0.05), and M-CSF+ FSH further stimulated higher production of E(2) and P by LGC than M-CSF or FSH alone (P < 0.05). Estradiol colony stimulating factor 1 Homo sapiens
4 M-CSF enhances estradiol and progesterone production by LGC and FSH has an additional or synergetic effect with M-CSF. Estradiol colony stimulating factor 1 Homo sapiens