Pub. Date : 2002 Sep 20
PMID : 12121973
3 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
1 | Treatment of NCI-H82 cells with etoposide induces a series of time-dependent events, including the release of cytochrome c from the mitochondria to the cytosol, activation of caspase-9 and caspase-3, and cleavage of poly(ADP-ribose) polymerase (PARP). | Etoposide | poly(ADP-ribose) polymerase 1 | Homo sapiens |
2 | Treatment of NCI-H82 cells with etoposide induces a series of time-dependent events, including the release of cytochrome c from the mitochondria to the cytosol, activation of caspase-9 and caspase-3, and cleavage of poly(ADP-ribose) polymerase (PARP). | Etoposide | poly(ADP-ribose) polymerase 1 | Homo sapiens |
3 | Furthermore, caspase-specific inhibitors, z-VAD-fmk and z-DEVD-fmk, significantly attenuate the accumulation of sub-G(1) population and block the PARP cleavage in response to etoposide. | Etoposide | poly(ADP-ribose) polymerase 1 | Homo sapiens |