Title : Protein kinase C-epsilon promotes survival of lung cancer cells by suppressing apoptosis through dysregulation of the mitochondrial caspase pathway.

Pub. Date : 2002 Sep 20

PMID : 12121973






3 Functional Relationships(s)
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1 Treatment of NCI-H82 cells with etoposide induces a series of time-dependent events, including the release of cytochrome c from the mitochondria to the cytosol, activation of caspase-9 and caspase-3, and cleavage of poly(ADP-ribose) polymerase (PARP). Etoposide poly(ADP-ribose) polymerase 1 Homo sapiens
2 Treatment of NCI-H82 cells with etoposide induces a series of time-dependent events, including the release of cytochrome c from the mitochondria to the cytosol, activation of caspase-9 and caspase-3, and cleavage of poly(ADP-ribose) polymerase (PARP). Etoposide poly(ADP-ribose) polymerase 1 Homo sapiens
3 Furthermore, caspase-specific inhibitors, z-VAD-fmk and z-DEVD-fmk, significantly attenuate the accumulation of sub-G(1) population and block the PARP cleavage in response to etoposide. Etoposide poly(ADP-ribose) polymerase 1 Homo sapiens