Title : Interleukin-22 (IL-22) activates the JAK/STAT, ERK, JNK, and p38 MAP kinase pathways in a rat hepatoma cell line. Pathways that are shared with and distinct from IL-10.

Pub. Date : 2002 Sep 13

PMID : 12087100






1 Functional Relationships(s)
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1 We found that IL-22 induces activation of JAK1 and Tyk2 but not JAK2, as well as phosphorylation of STAT1, STAT3, and STAT5 on tyrosine residues, extending the similarities between IL-22 and IL-10. Tyrosine signal transducer and activator of transcription 1 Rattus norvegicus