| Protein Name | signal transducer and activator of transcription 1 |
|---|---|
| Organism | Rattus norvegicus |
| Gene ID | 25124 |
| Gene Symbol | Stat1 |
| UniProt | F1M9D6 (F1M9D6_RAT), Q6P6Q7 (Q6P6Q7_RAT), Q9QXK0 (Q9QXK0_RAT) |
| Relationships |
Total Number of functionally related compound(s) :
148
Total Number of Articles : 193 |
Description |
signal transducer and activator of transcription 1 |
| Gene Summary |
Enables CCR5 chemokine receptor binding activity; protein phosphatase 2A binding activity; and sequence-specific DNA binding activity. Involved in several processes, including cell surface receptor signaling pathway via JAK-STAT; positive regulation of nitric oxide biosynthetic process; and positive regulation of smooth muscle cell proliferation. Acts upstream of or within cellular response to cytokine stimulus. Located in axon and dendrite. Used to study pulmonary fibrosis. Human ortholog(s) of this gene implicated in adenocarcinoma (multiple); breast cancer (multiple); immunodeficiency 31A; immunodeficiency 31B; and immunodeficiency 31C. Orthologous to human STAT1 (signal transducer and activator of transcription 1). [provided by Alliance of Genome Resources, Jun 2025] |
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| Properties | |