Pub. Date : 2002 Jul
PMID : 12086980
5 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | In cultured endothelial cells, Delta(9)-tetrahydrocannabinol (Delta(9)-THC) and the cannabinoid receptor agonist HU210, increased the phosphorylation of extracellular regulated kinases 1/2 (ERK1/2) and inhibited gap junctional communication, as determined by Lucifer Yellow dye transfer and electrical capacity measurements. | Dronabinol | mitogen-activated protein kinase 3 | Homo sapiens |
| 2 | In cultured endothelial cells, Delta(9)-tetrahydrocannabinol (Delta(9)-THC) and the cannabinoid receptor agonist HU210, increased the phosphorylation of extracellular regulated kinases 1/2 (ERK1/2) and inhibited gap junctional communication, as determined by Lucifer Yellow dye transfer and electrical capacity measurements. | Dronabinol | mitogen-activated protein kinase 3 | Homo sapiens |
| 3 | Delta(9)-THC elicited a pronounced increase in the phosphorylation of connexin 43, which was sensitive to PD98059 and U0126, two inhibitors of ERK1/2 activation. | Dronabinol | mitogen-activated protein kinase 3 | Homo sapiens |
| 4 | Inhibition of ERK1/2 also prevented the Delta(9)-THC-induced inhibition of gap junctional communication. | Dronabinol | mitogen-activated protein kinase 3 | Homo sapiens |
| 5 | These results indicate that the cannabinoid-induced activation of ERK1/2, which leads to the phosphorylation of connexin 43 and inhibition of gap junctional communication, may partially account for the Delta(9)-THC-induced inhibition of EDHF-mediated relaxation. | Dronabinol | mitogen-activated protein kinase 3 | Homo sapiens |