Title : Superoxide anion-dependent Raf/MEK/ERK activation by peroxisome proliferator activated receptor gamma agonists 15-deoxy-delta(12,14)-prostaglandin J(2), ciglitazone, and GW1929.

Pub. Date : 2002 Jul 15

PMID : 12083801






2 Functional Relationships(s)
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1 Chemiluminescence study reveals that these three PPARgamma agonists are able to induce superoxide anion production, with an efficacy similar to their action on ERK phosphorylation. Superoxides peroxisome proliferator activated receptor gamma Homo sapiens
2 In this study, we for the first time demonstrate a novel mechanism, independent of Ras activation but initiated by superoxide anion production, for PPARgamma agonists to trigger the Raf-MEK-ERK1/2 signaling pathway. Superoxides peroxisome proliferator activated receptor gamma Homo sapiens