Pub. Date : 2002 Jul 1
PMID : 12077223
3 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | Agents that increase cAMP, such as PGE(2), inhibit human CD4(+) T cell activation. | Cyclic AMP | CD4 molecule | Homo sapiens |
| 2 | We demonstrate that several ATP derivatives increase cAMP in both freshly purified and activated human peripheral blood CD4(+) T cells. | Cyclic AMP | CD4 molecule | Homo sapiens |
| 3 | Taken together, our results suggest that extracellular adenine nucleotides inhibit CD4(+) T cell activation via an increase in cAMP mediated by an unidentified P2YR, which might thus constitute a new therapeutic target in immunosuppressive treatments. | Cyclic AMP | CD4 molecule | Homo sapiens |