Title : Analysis of the structural basis of specificity of inhibition of the Abl kinase by STI571.

Pub. Date : 2002 Aug 30

PMID : 12077114






1 Functional Relationships(s)
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1 Co-crystallization studies of Abl kinase and an STI571-related compound identify specific amino acid residues as critical to STI571 binding, one of which, T315, has been characterized as an acquired Thr to Ile mutation in relapsed patients. Threonine ABL proto-oncogene 1, non-receptor tyrosine kinase Homo sapiens