Title : Effect of albumin and cytosol on enzyme kinetics of tolbutamide hydroxylation and on inhibition of CYP2C9 by gemfibrozil in human liver microsomes.

Pub. Date : 2002 Jul

PMID : 12065698






2 Functional Relationships(s)
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1 Effect of albumin and cytosol on enzyme kinetics of tolbutamide hydroxylation and on inhibition of CYP2C9 by gemfibrozil in human liver microsomes. Gemfibrozil cytochrome P450 family 2 subfamily C member 9 Homo sapiens
2 The K(i) (6 microM) of gemfibrozil for CYP2C9, calculated using total drug concentrations, was increased by Hlc (8 microM), Hsa (40 microM), or both (72 microM). Gemfibrozil cytochrome P450 family 2 subfamily C member 9 Homo sapiens