Pub. Date : 2002 Apr
PMID : 12064480
3 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | DARPP-32, a dopamine- and cAMP-regulated phosphoprotein of Mr 32 kDa, is phosphorylated on Thr34 by cAMP-dependent protein kinase, resulting in its conversion into a potent inhibitor of protein phosphatase-1 (PP 1). | Dopamine | protein phosphatase 1, regulatory inhibitor subunit 1B | Mus musculus |
| 2 | These results indicate that neurotensin stimulates the release of dopamine from nigrostriatal presynaptic terminals in an NMDA receptor- and AMPA receptor-dependent manner, leading to the increase in DARPP-32 Thr34 phosphorylation. | Dopamine | protein phosphatase 1, regulatory inhibitor subunit 1B | Mus musculus |
| 3 | Thus, neurotensin, by stimulating the release of dopamine, activates the dopamine D1-receptor/cAMP/PKA/DARPP-32/PP 1 cascade. | Dopamine | protein phosphatase 1, regulatory inhibitor subunit 1B | Mus musculus |