Pub. Date : 2002 Aug 23
PMID : 12063261
7 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | A novel adenine nucleotide translocase inhibitor, MT-21, induces cytochrome c release by a mitochondrial permeability transition-independent mechanism. | MT 21 | solute carrier family 25 member 6 | Homo sapiens |
| 2 | We demonstrate that MT-21 significantly inhibits ADP transport activity in mitochondria and reduces binding of the adenine nucleotide translocase (ANT) to a phenylarsine oxide affinity matrix. | MT 21 | solute carrier family 25 member 6 | Homo sapiens |
| 3 | We demonstrate that MT-21 significantly inhibits ADP transport activity in mitochondria and reduces binding of the adenine nucleotide translocase (ANT) to a phenylarsine oxide affinity matrix. | MT 21 | solute carrier family 25 member 6 | Homo sapiens |
| 4 | In agreement with this, the MT-21-induced cytochrome c release was effectively inhibited in the presence of ANT ligands, and MT-21 could dissociate ANT from a complex with a glutathione S-transferase-cyclophilin D fusion protein. | MT 21 | solute carrier family 25 member 6 | Homo sapiens |
| 5 | In agreement with this, the MT-21-induced cytochrome c release was effectively inhibited in the presence of ANT ligands, and MT-21 could dissociate ANT from a complex with a glutathione S-transferase-cyclophilin D fusion protein. | MT 21 | solute carrier family 25 member 6 | Homo sapiens |
| 6 | In agreement with this, the MT-21-induced cytochrome c release was effectively inhibited in the presence of ANT ligands, and MT-21 could dissociate ANT from a complex with a glutathione S-transferase-cyclophilin D fusion protein. | MT 21 | solute carrier family 25 member 6 | Homo sapiens |
| 7 | Interestingly, we also found that specific inhibitors of ANT such as MT-21 and atractyloside could induce cytochrome c release without mitochondrial swelling and that this event was highly dependent on the presence of Mg(2+). | MT 21 | solute carrier family 25 member 6 | Homo sapiens |