PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 12063261-0 2002 A novel adenine nucleotide translocase inhibitor, MT-21, induces cytochrome c release by a mitochondrial permeability transition-independent mechanism. MT 21 50-55 solute carrier family 25 member 6 Homo sapiens 8-38 12063261-3 2002 We demonstrate that MT-21 significantly inhibits ADP transport activity in mitochondria and reduces binding of the adenine nucleotide translocase (ANT) to a phenylarsine oxide affinity matrix. MT 21 20-25 solute carrier family 25 member 6 Homo sapiens 115-145 12063261-3 2002 We demonstrate that MT-21 significantly inhibits ADP transport activity in mitochondria and reduces binding of the adenine nucleotide translocase (ANT) to a phenylarsine oxide affinity matrix. MT 21 20-25 solute carrier family 25 member 6 Homo sapiens 147-150 12063261-5 2002 In agreement with this, the MT-21-induced cytochrome c release was effectively inhibited in the presence of ANT ligands, and MT-21 could dissociate ANT from a complex with a glutathione S-transferase-cyclophilin D fusion protein. MT 21 28-33 solute carrier family 25 member 6 Homo sapiens 108-111 12063261-5 2002 In agreement with this, the MT-21-induced cytochrome c release was effectively inhibited in the presence of ANT ligands, and MT-21 could dissociate ANT from a complex with a glutathione S-transferase-cyclophilin D fusion protein. MT 21 28-33 solute carrier family 25 member 6 Homo sapiens 148-151 12063261-5 2002 In agreement with this, the MT-21-induced cytochrome c release was effectively inhibited in the presence of ANT ligands, and MT-21 could dissociate ANT from a complex with a glutathione S-transferase-cyclophilin D fusion protein. MT 21 125-130 solute carrier family 25 member 6 Homo sapiens 148-151 12063261-6 2002 Interestingly, we also found that specific inhibitors of ANT such as MT-21 and atractyloside could induce cytochrome c release without mitochondrial swelling and that this event was highly dependent on the presence of Mg(2+). MT 21 69-74 solute carrier family 25 member 6 Homo sapiens 57-60