Title : Importance of FADD signaling in serum deprivation- and hypoxia-induced cardiomyocyte apoptosis.

Pub. Date : 2002 Aug 30

PMID : 12063258






1 Functional Relationships(s)
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1 The combination of SD and hypoxia induced rapid activation of caspase-3 and -8 as well as DNA fragmentation, reaching a plateau within 4-8 h. Adenoviral expression of FADD-dn inhibited caspase-8 activation as well as hypoxia/SD-induced apoptosis at 24 h in an moi (multiplicity of infection)-dependent manner. SD 0006 caspase 8 Rattus norvegicus