Title : Evidence for the involvement of CYP1A2 in the metabolism of bromodichloromethane in rat liver.

Pub. Date : 2002 Jul 1

PMID : 12062927






6 Functional Relationships(s)
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1 Inhibition of CYP1A2, with isosafrole, reduced the metabolism and toxicity of BDCM in the previously induced rats. isosafrole cytochrome P450, family 1, subfamily a, polypeptide 2 Rattus norvegicus
2 Activity data show that only CYP1A2 was inhibited by isosafrole; isosafrole forms a complex with CYP1A2 that persists for more than 24 h. Western blot results generally agree with the activity data except that isosafrole induced the protein for all isoenzymes measured. isosafrole cytochrome P450, family 1, subfamily a, polypeptide 2 Rattus norvegicus
3 Activity data show that only CYP1A2 was inhibited by isosafrole; isosafrole forms a complex with CYP1A2 that persists for more than 24 h. Western blot results generally agree with the activity data except that isosafrole induced the protein for all isoenzymes measured. isosafrole cytochrome P450, family 1, subfamily a, polypeptide 2 Rattus norvegicus
4 Activity data show that only CYP1A2 was inhibited by isosafrole; isosafrole forms a complex with CYP1A2 that persists for more than 24 h. Western blot results generally agree with the activity data except that isosafrole induced the protein for all isoenzymes measured. isosafrole cytochrome P450, family 1, subfamily a, polypeptide 2 Rattus norvegicus
5 Activity data show that only CYP1A2 was inhibited by isosafrole; isosafrole forms a complex with CYP1A2 that persists for more than 24 h. Western blot results generally agree with the activity data except that isosafrole induced the protein for all isoenzymes measured. isosafrole cytochrome P450, family 1, subfamily a, polypeptide 2 Rattus norvegicus
6 Activity data show that only CYP1A2 was inhibited by isosafrole; isosafrole forms a complex with CYP1A2 that persists for more than 24 h. Western blot results generally agree with the activity data except that isosafrole induced the protein for all isoenzymes measured. isosafrole cytochrome P450, family 1, subfamily a, polypeptide 2 Rattus norvegicus