Title : Electrostatic interactions in ubiquitin: stabilization of carboxylates by lysine amino groups.

Pub. Date : 2002 Jun 18

PMID : 12056889






1 Functional Relationships(s)
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1 NMR studies with these six single-site mutants reveal significant interactions of Lys 11 and Lys 29 with Glu 34 and Asp 21, respectively: pK(a) values for Glu 34 and Asp 21 increase by approximately 0.5-0.8 pH unit, similar to predicted values, when the lysines are replaced by neutral residues. Glutamic Acid beta-secretase 2 Homo sapiens