Pub. Date : 2002 Apr 26
PMID : 12054639
4 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | Flavopiridol has been shown to potently inhibit CDK1 and 2 (cyclin-dependent kinases 1 and 2) and most recently it has been found that it also inhibits CDK9. | alvocidib | cyclin dependent kinase 1 | Homo sapiens |
| 2 | Flavopiridol has been shown to potently inhibit CDK1 and 2 (cyclin-dependent kinases 1 and 2) and most recently it has been found that it also inhibits CDK9. | alvocidib | cyclin dependent kinase 1 | Homo sapiens |
| 3 | This structural model indicates that the inhibitor strongly binds to the ATP-binding pocket of CDK9 and the structural comparison of the complex CDK2-flavopiridol correlates the structural differences with differences in inhibition of these CDKs by flavopiridol. | alvocidib | cyclin dependent kinase 1 | Homo sapiens |
| 4 | This structural model indicates that the inhibitor strongly binds to the ATP-binding pocket of CDK9 and the structural comparison of the complex CDK2-flavopiridol correlates the structural differences with differences in inhibition of these CDKs by flavopiridol. | alvocidib | cyclin dependent kinase 1 | Homo sapiens |