Pub. Date : 2002 May 28
PMID : 12052248
4 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | Release of annexin V-binding membrane microparticles from cultured human umbilical vein endothelial cells after treatment with camptothecin. | Camptothecin | annexin A5 | Homo sapiens |
| 2 | In contrast, induction of apoptosis with 5 microM camptothecin, documented by 60-70% desquamation of HUVEC culture, annexin V-binding to the cells and DNA-fragmentation, led to a release of annexin V-binding microparticles (approximately 80,000 MP/103 cells). | Camptothecin | annexin A5 | Homo sapiens |
| 3 | In contrast, induction of apoptosis with 5 microM camptothecin, documented by 60-70% desquamation of HUVEC culture, annexin V-binding to the cells and DNA-fragmentation, led to a release of annexin V-binding microparticles (approximately 80,000 MP/103 cells). | Camptothecin | annexin A5 | Homo sapiens |
| 4 | CONCLUSIONS: Camptothecin treated HUVEC released different populations of annexin V-binding membrane microparticles at early stage after proapoptotic stimulation before detection of phosphatidylserine exposure on the cells or DNA fragmentation. | Camptothecin | annexin A5 | Homo sapiens |