Pub. Date : 2002 May
PMID : 12049736
4 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | Phosphorylation on tyrosine-15 of p34(Cdc2) by ErbB2 inhibits p34(Cdc2) activation and is involved in resistance to taxol-induced apoptosis. | Paclitaxel | cyclin dependent kinase 1 | Homo sapiens |
| 2 | ErbB2 overexpression confers resistance to taxol-induced apoptosis by inhibiting p34(Cdc2) activation. | Paclitaxel | cyclin dependent kinase 1 | Homo sapiens |
| 3 | Expressing a nonphosphorylatable mutant of Cdc2 renders cells more sensitive to taxol-induced apoptosis. | Paclitaxel | cyclin dependent kinase 1 | Homo sapiens |
| 4 | Thus, ErbB2 membrane RTK can confer resistance to taxol-induced apoptosis by directly phosphorylating Cdc2. | Paclitaxel | cyclin dependent kinase 1 | Homo sapiens |