Title : Functional role of p38 mitogen activated protein kinase in platelet activation induced by a thromboxane A2 analogue and by 8-iso-prostaglandin F2alpha.

Pub. Date : 2002 May

PMID : 12038794






2 Functional Relationships(s)
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1 These platelet responses were also inhibited by 20 micromol/L cytochalasin D, an inhibitor of actin polymerization, and 50 micromol/L piceatannol, an inhibitor of the Syk tyrosine kinases. 3,3',4,5'-tetrahydroxystilbene spleen associated tyrosine kinase Homo sapiens
2 Both 8-iso-PGF2alpha and U46619-induced p38 MAP kinase phosphorylation in suspended platelets and this was inhibited by piceatannol, indicating that Syk activation occurs upstream of p38 MAP kinase phosphorylation. 3,3',4,5'-tetrahydroxystilbene spleen associated tyrosine kinase Homo sapiens