Title : Proton demand inversion in a mutant protein tyrosine kinase reaction.

Pub. Date : 2002 May 29

PMID : 12022825






1 Functional Relationships(s)
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1 In contrast to previous studies that have shown that the neutral phenol serves as the nucleophile for WT Csk-promoted phosphorylation of a tyrosine-containing substrate, the phenolate ion acts as primary nucleophile for the D314N Csk-catalyzed reaction. Tyrosine C-terminal Src kinase Homo sapiens