Title : An algorithm-directed two-component library synthesized via solid-phase methodology yielding potent and orally bioavailable p38 MAP kinase inhibitors.

Pub. Date : 2002 May 23

PMID : 12014955






1 Functional Relationships(s)
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1 Previously we reported the identification of RPR200765A, a potent orally bioavailable pyridine-imidazole inhibitor of p38 mitogen-activated protein (MAP) kinase which suppressed paw swelling and joint pathology in streptococcal cell wall-induced arthritis. pyridine mitogen-activated protein kinase 14 Homo sapiens