Pub. Date : 2002 Jun
PMID : 11997521
3 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | In this study, we show that stimulation of C2C12 myoblasts with FGF-2 induces SHP-2 complex formation with tyrosyl-phosphorylated FGFR substrate 2 alpha (FRS-2 alpha). | cyclo(tyrosyl-tyrosyl) | protein tyrosine phosphatase non-receptor type 11 | Homo sapiens |
| 2 | Both the catalytic activity and, to a much lesser extent, the Grb2 binding-tyrosyl phosphorylation sites of SHP-2 are required for maximal FGF-2-induced Erk activity and Elk-1 transactivation. | cyclo(tyrosyl-tyrosyl) | protein tyrosine phosphatase non-receptor type 11 | Homo sapiens |
| 3 | The constitutively active mutant of SHP-2 induces hyper-tyrosyl phosphorylation of FRS-2 alpha but fails to stimulate or potentiate either FGF-2-induced Erk activation or Elk-1 transactivation. | cyclo(tyrosyl-tyrosyl) | protein tyrosine phosphatase non-receptor type 11 | Homo sapiens |