Title : Increase of the resistance of human cervical carcinoma cells to cisplatin by inhibition of the MEK to ERK signaling pathway partly via enhancement of anticancer drug-induced NF kappa B activation.

Pub. Date : 2002 Apr 15

PMID : 11996883






2 Functional Relationships(s)
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Compound Name
Protein Name
Organism
1 Both cisplatin and doxorubicin activated nuclear ERK2 and nuclear transcription factor kappa B (NF kappa B) of SiHa cells. Doxorubicin nuclear factor kappa B subunit 1 Homo sapiens
2 The activation of NF kappa B by cisplatin or doxorubicin was not due to the degradation of cytoplasmic I kappa B alpha, as demonstrated by western blotting. Doxorubicin nuclear factor kappa B subunit 1 Homo sapiens