Title : Identification of potent and selective oxytocin antagonists. Part 1: indole and benzofuran derivatives.

Pub. Date : 2002 May 20

PMID : 11992786






2 Functional Relationships(s)
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1 Combinatorial libraries designed to find novel replacements of fragments of oxytocin antagonist L-371,257, identified pyrimidine, thiazole, indole and benzofuran as potential alternatives to the benzoic acid moiety of L-371,257. benzofuran oxytocin/neurophysin I prepropeptide Homo sapiens
2 Additional investigations identified indole and benzofuran derivatives with potent oxytocin antagonist activity. benzofuran oxytocin/neurophysin I prepropeptide Homo sapiens