Title : Design and synthesis of aminophenol-based factor Xa inhibitors.

Pub. Date : 2002 May 6

PMID : 11965377






2 Functional Relationships(s)
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1 A novel potent and selective aminophenol scaffold for fXa inhibitors was developed from a previously reported benzimidazole-based naphthylamidine template. Aminophenols coagulation factor X Homo sapiens
2 Substitution of a propenyl-para-hydroxy-benzamidine group on the aminophenol template produced selective, sub-nanomolar fXa inhibitors. Aminophenols coagulation factor X Homo sapiens