Title : Kinetic mechanism of activation of the Cdk2/cyclin A complex. Key role of the C-lobe of the Cdk.

Pub. Date : 2002 Jun 28

PMID : 11959850






1 Functional Relationships(s)
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1 The first step involves the rapid association between the PSTAIRE helix of Cdk2 and helices 3 and 5 of the cyclin to yield an intermediate complex in which the threonine in the T-loop is not accessible for phosphorylation. Threonine cyclin dependent kinase 2 Homo sapiens