Title : Pregna-D'-pentarane structure influences progesterone receptor affinity for DNA.

Pub. Date : 2002 Apr

PMID : 11958787






1 Functional Relationships(s)
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1 The highest affinity of PR to DNA (equilibrium K(a) = 0.420 +/- 0.185 nM(-1)) was found in the presence of the partial agonist/antagonist RU486, while the lowest affinity (K(a) = 0.074 +/- 0.013 nM(-1)) was demonstrated with the full agonist 6alpha-methyl-16alpha,17alpha-cyclohexanoprogesterone. 6alpha-methyl-16alpha progesterone receptor Rattus norvegicus