Pub. Date : 2002 Jun 14
PMID : 11950832
4 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | Regulation of T cell receptor CD3zeta chain expression by L-arginine. | Arginine | CD247 molecule | Homo sapiens |
| 2 | The data presented here demonstrate that Jurkat T cells cultured in medium without L-Arg (L-Arg-free RPMI) have a rapid decrease in the expression of the T cell antigen receptor zeta chain (CD3zeta), the principal signal transduction element in this receptor, and a decrease in T cell proliferation. | Arginine | CD247 molecule | Homo sapiens |
| 3 | The data presented here demonstrate that Jurkat T cells cultured in medium without L-Arg (L-Arg-free RPMI) have a rapid decrease in the expression of the T cell antigen receptor zeta chain (CD3zeta), the principal signal transduction element in this receptor, and a decrease in T cell proliferation. | Arginine | CD247 molecule | Homo sapiens |
| 4 | Therefore, the regulation of L-Arg concentration in the microenvironment could represent an important mechanism to modulate the expression of CD3zeta and the T cell receptor and consequently of T cell function. | Arginine | CD247 molecule | Homo sapiens |