Title : Dopaminergic transmission in the rat striatum in vivo in conditions of pharmacological modulation.

Pub. Date : 2002 Mar-Apr

PMID : 11942697






2 Functional Relationships(s)
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1 Inhibition of catechol O-methyltransferase (COMT) with tolcapone led to increases in extracellular dopamine levels only when the baseline dopamine level was elevated by administration of L-3,4-dihydroxyphenylalanine in combination with the decarboxylation inhibitor carbidopa. Carbidopa catechol-O-methyltransferase Rattus norvegicus
2 Inhibition of catechol O-methyltransferase (COMT) with tolcapone led to increases in extracellular dopamine levels only when the baseline dopamine level was elevated by administration of L-3,4-dihydroxyphenylalanine in combination with the decarboxylation inhibitor carbidopa. Carbidopa catechol-O-methyltransferase Rattus norvegicus