Pub. Date : 2002 Apr
PMID : 11927498
4 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | CYP2A6 activity determined by caffeine phenotyping: association with colorectal cancer risk. | Caffeine | cytochrome P450 family 2 subfamily A member 6 | Homo sapiens |
| 2 | CYP2A6 phenotype was determined using caffeine as a probe drug in individuals participating in a case-control study of colorectal cancer (127 cases and 333 controls matched on age, gender, race, and geographic region). | Caffeine | cytochrome P450 family 2 subfamily A member 6 | Homo sapiens |
| 3 | Conversion of the caffeine metabolite 1,7-dimethylxanthine (17X) to 1,7-dimethyl uric acid (17U) is catalyzed primarily by CYP2A6, and this activity can be assayed by comparison of urinary molar ratios of metabolites. | Caffeine | cytochrome P450 family 2 subfamily A member 6 | Homo sapiens |
| 4 | We found a strong relationship between CYP2A6 activity, measured by urinary caffeine metabolite ratio, and colorectal cancer risk. | Caffeine | cytochrome P450 family 2 subfamily A member 6 | Homo sapiens |