Title : Involvement of the alpha3 subunit in central nicotinic binding populations.

Pub. Date : 2002 Apr 1

PMID : 11923417






2 Functional Relationships(s)
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1 Heterologously expressed alpha3beta2 and alpha3beta4 nAChRs are pharmacologically similar to native [125I]alpha-conotoxin MII (alpha-CtxMII)-binding and 3-(2(S)-azetidinylmethoxy)pyridine dihydrochloride (A85380)-resistant [125I]epibatidine-binding nAChR subtypes, respectively. epibatidine cholinergic receptor, nicotinic, alpha polypeptide 7 Mus musculus
2 In contrast, most -resistant [125I]epibatidine-binding nAChRs were dependent on alpha3 gene expression, suggesting that they do indeed correspond to an alpha3 nAChR subtype. epibatidine cholinergic receptor, nicotinic, alpha polypeptide 7 Mus musculus