Title : Impact of HMG CoA reductase inhibition on small GTPases in the heart.

Pub. Date : 2002 Mar

PMID : 11922901






1 Functional Relationships(s)
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1 To test these findings in vivo, spontaneously hypertensive rats were treated with atorvastatin, leading to a decrease in cardiac Rac1 and RhoA activity as determined by [35S]-GTP gamma S-binding assays by 61+/-16% and 72+/-24%, and downregulation of MLC-2 as well as ANF mRNA expression by 31+/-16% and 80+/-24%, respectively. Atorvastatin natriuretic peptide A Rattus norvegicus