Pub. Date : 2000
PMID : 11920189
8 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | von Willebrand factor binding to heparin in various types of von Willebrand disease. | Heparin | von Willebrand factor | Homo sapiens |
| 2 | INTRODUCTION: The purpose was to study von Willebrand factor (vWF) binding to heparin in different types of von Willebrand disease (vWD). | Heparin | von Willebrand factor | Homo sapiens |
| 3 | INTRODUCTION: The purpose was to study von Willebrand factor (vWF) binding to heparin in different types of von Willebrand disease (vWD). | Heparin | von Willebrand factor | Homo sapiens |
| 4 | We determined the range of vWF concentrations in plasma where the percentage of (125)I-MAb/vWF complexes bound to heparin-agarose beads was constant. | Heparin | von Willebrand factor | Homo sapiens |
| 5 | We determined the range of vWF concentrations in plasma where the percentage of (125)I-MAb/vWF complexes bound to heparin-agarose beads was constant. | Heparin | von Willebrand factor | Homo sapiens |
| 6 | RESULTS: The multimeric composition of vWF had hardly any influence on the ability of vWF to bind to heparin. | Heparin | von Willebrand factor | Homo sapiens |
| 7 | Furthermore, when comparing the mean values of plasma vWF-heparin binding ratios by ANOVA F-test in the six groups (one normal and five vWD), we found significant differences between them (P<0.0001). | Heparin | von Willebrand factor | Homo sapiens |
| 8 | CONCLUSION: Our data suggest a relationship between the ability of vWF to bind to heparin and to the platelet GPIb receptor, since type 2B and 2N patients have an increased or normal ability to bind to GPIb whereas type 2A and 2M patients have an impaired interaction with that receptor. | Heparin | von Willebrand factor | Homo sapiens |