Pub. Date : 2002 Mar
PMID : 11897997
6 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | OBJECTIVE: We examined the effects of dexamethasone (DEX) on beta(2)AR gene expression and the function of the beta(2)AR-AC system in cultured human airway epithelial cells. | Dexamethasone | adrenoceptor beta 2 | Homo sapiens |
| 2 | OBJECTIVE: We examined the effects of dexamethasone (DEX) on beta(2)AR gene expression and the function of the beta(2)AR-AC system in cultured human airway epithelial cells. | Dexamethasone | adrenoceptor beta 2 | Homo sapiens |
| 3 | The function of the beta(2)AR-AC system was assessed from cAMP production in response to the beta(2)-agonist isoproterenol and the expression of the stimulatory G protein G(alpha)s. RESULTS: DEX had no effect on beta-adrenergic receptor density or on the beta(1)/beta(2) ratio over a wide range of concentrations and exposure times. | Dexamethasone | adrenoceptor beta 2 | Homo sapiens |
| 4 | However, DEX significantly but transiently enhanced beta(2)AR mRNA levels (approximately 1.5-fold) and beta(2)AR promoter activity (approximately 1.5-fold), indicating increased beta(2)AR gene transcription. | Dexamethasone | adrenoceptor beta 2 | Homo sapiens |
| 5 | However, DEX significantly but transiently enhanced beta(2)AR mRNA levels (approximately 1.5-fold) and beta(2)AR promoter activity (approximately 1.5-fold), indicating increased beta(2)AR gene transcription. | Dexamethasone | adrenoceptor beta 2 | Homo sapiens |
| 6 | However, DEX significantly but transiently enhanced beta(2)AR mRNA levels (approximately 1.5-fold) and beta(2)AR promoter activity (approximately 1.5-fold), indicating increased beta(2)AR gene transcription. | Dexamethasone | adrenoceptor beta 2 | Homo sapiens |