Title : Rac activation induces NADPH oxidase activity in transgenic COSphox cells, and the level of superoxide production is exchange factor-dependent.

Pub. Date : 2002 May 24

PMID : 11896053






1 Functional Relationships(s)
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1 The constitutively active form of the hematopoietic-specific GEF, Vav1, was the most effective at activating superoxide production, despite detection of higher levels of Rac1-GTP upon expression of constitutively active Vav2 or Tiam1 derivatives. Superoxides vav guanine nucleotide exchange factor 1 Homo sapiens